Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.31 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242250 | 0.83 | — | — | |
| Trifluoroacetic Acid SCHEMBL28148714 | 0.82 | MEN1 (0.36) | MEN1KMT2AFFAR3CHIT1FUCA1 | |
| Hydrochloric Acid SCHEMBL2227956 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL15414360 | 0.81 | — | — | |
| Trifluoroacetic Acid SCHEMBL28048228 | 0.80 | KDM4E (0.48) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Trifluoroacetic Acid SCHEMBL7105511 | 0.76 | CTSD (0.44) | KDM4EKDM5CPHF8KDM2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL3272755 | 0.75 | KDM4E (0.34) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Trifluoroacetic Acid SCHEMBL29019087 | 0.74 | FUCA1 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1FFAR3 | |
| Trifluoroacetic Acid SCHEMBL4485807 | 0.73 | FFAR3 (0.62) | MEN1KMT2AALDH1A1FFAR3HDAC3 | |
| Trifluoroacetic Acid SCHEMBL20527475 | 0.73 | FFAR3 (0.62) | MEN1KMT2AALDH1A1FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470940-B | The purposes of 2- oxos -2,3,4,5- tetrahydrochysene -1H- benzos [b] [Isosorbide-5-Nitrae] diaza * and its treating cancer | 霍夫曼-拉罗奇有限公司 | 2018-10-16 | — | — | CN | disclosed |
| EP-3071562-A1 | TETRAHYDRO-BENZODIAZEPINONES | F. Hoffmann-La Roche AG (CH) | 2016-09-28 | — | — | EP | disclosed |
| US-9422331-B2 | 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer | HOFFMANN-LA ROCHE INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150225449-A1 | 2-OXO-2,3,4,5-TETRAHYDRO-1 H-BENZO[B]DIAZEPINES AND THEIR USE IN THE TREATMENT OF CANCER | HOFFMANN-LA ROCHE INC. | 2015-08-13 | — | — | US | disclosed |
| WO-2015071393-A1 | TETRAHYDRO-BENZODIAZEPINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225449-A1 | 2-OXO-2,3,4,5-TETRAHYDRO-1 H-BENZO[B]DIAZEPINES AND THEIR USE IN THE TREATMENT OF CANCER | H1-5, HRH2, TOP2B | KDM4E 963/4885KDM5C 514/4885EGLN1 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.