SCHEMBL16718967

SCHEMBL16718967

O=S(=O)(NC(Cc1ccccc1)c1cncn1CCc1ccc(F)cc1)c1cccnc1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 6/20 0.41
TBXAS1 P24557 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
TAAR1 Q96RJ0 1/20 0.39
GNRHR P30968 1/20 0.38
SLC1A3 P43003 1/20 0.38
SLC1A2 P43004 1/20 0.38
SLC1A1 P43005 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
PTPN2 P17706 1/20 0.37
PTPN1 P18031 1/20 0.37
TSHR P16473 1/20 0.37
PAX8 Q06710 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16720943 0.74 MEN1 (0.39) TAAR1GNRHRTSHRPAX8
SCHEMBL16718965 0.74 TAAR1 (0.42) TBXAS1TAAR1GNRHR
SCHEMBL750261 0.68 MEN1 (0.58) SMN1; SMN2PAX8
SCHEMBL9417324 0.68 MMP2 (0.65) SLC1A3SLC1A2SLC1A1
SCHEMBL533136 0.67 PTGER2 (0.61)
Hydrochloric Acid SCHEMBL533772 0.67 PTGER2 (0.61)
SCHEMBL8285900 0.66 PTGER2 (0.51) TBXAS1SMN1; SMN2
SCHEMBL8895298 0.63 NPSR1 (0.50) TBXAS1NPSR1TAAR1SMN1; SMN2
SCHEMBL18725052 0.63 KEAP1 (0.71) SMN1; SMN2PAX8
SCHEMBL784028 0.63 SLC1A3 (0.56) S1PR1SLC1A3SLC1A2SLC1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068391-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG Merck Sharp & Dohme Corp. (US) 2016-09-21 EP claimed
WO-2015073308-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG MERCK SHARP & DOHME CORP. (US) 2015-05-21 WO claimed
WO-2015070366-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG MERCK SHARP & DOHME CORP. (US) 2015-05-21 WO claimed
EP-3068391-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG Merck Sharp & Dohme Corp. (US) 2016-09-21 EP disclosed
WO-2015073308-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG MERCK SHARP & DOHME CORP. (US) 2015-05-21 WO disclosed
WO-2015070366-A1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG MERCK SHARP & DOHME CORP. (US) 2015-05-21 WO disclosed