Pyrazine

Pyrazine

SCHEMBL1671928

c1c[nH]cn1.c1cnccn1

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.87
FKBP5 Q13451 1/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrazine SCHEMBL28078427 1.00 ALDH1A1 (0.87) ALDH1A1FKBP5
Imidazole SCHEMBL28744226 0.93 ALDH1A1 (1.00) ALDH1A1FKBP5
Imidazole SCHEMBL1331920 0.93
Imidazole SCHEMBL19028065 0.93 ALDH1A1 (1.00) ALDH1A1FKBP5
Imidazole SCHEMBL2684565 0.93 ALDH1A1 (1.00) ALDH1A1FKBP5
Imidazole SCHEMBL30382963 0.93
Imidazole SCHEMBL1331382 0.93
Imidazole SCHEMBL897 0.93
Imidazole SCHEMBL2635292 0.93
Pyrazine SCHEMBL8970869 0.91 ALDH1A1 (0.72) ALDH1A1FKBP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 655 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112018248-B Display device and preparation method thereof 固安鼎材科技有限公司 2023-12-29 CN claimed
US-20220119270-A1 CERIA NANOPARTICLES AND CERIA NANOPARTICLES PREPARATION METHOD Research & Business Foundation Sungkyunkwan University (KR) 2022-04-21 US claimed
CN-106715420-A crosslinkable host material 西诺拉股份有限公司 2017-05-24 CN claimed
CN-106084187-A Polymer, crosslinked polymer and the electroluminescent device comprising described polymer 默克专利有限公司 2016-11-09 CN claimed
CN-103980281-B A kind of imidazoles pyrazine compound and preparation method thereof 天津市斯芬克司药物研发有限公司 2016-06-08 CN claimed
CN-103980281-A Imidazole pyrazine compound and preparation method thereof SPHINX SCIENT LAB CORP 2014-08-13 CN claimed
EP-1027713-A4 NONAQUEOUS ELECTROLYTE FOR ELECTRICAL STORAGE DEVICES COVALENT ASSOCIATES INC (US) 2004-08-11 EP claimed
EP-1232206-A1 ANTISTATIC COMPOSITION 3M Innovative Properties Company (US) 2002-08-21 EP claimed
WO-2001025326-A1 ANTISTATIC COMPOSITION 3M INNOVATIVE PROPERTIES COMPANY (US) 2001-04-12 WO claimed
EP-1027713-A1 NONAQUEOUS ELECTROLYTE FOR ELECTRICAL STORAGE DEVICES COVALENT ASSOCIATES INCORPORATED (US) 2000-08-16 EP claimed
WO-1999008299-A1 NONAQUEOUS ELECTROLYTE FOR ELECTRICAL STORAGE DEVICES COVALENT ASSOCIATES, INC. (US) 1999-02-18 WO claimed
EP-0042210-B1 PALLADIUM(II) BIS (HEXAFLUOROACETYLACETONATE), ADDUCTS DERIVED THEREFROM AND USES THEREOF MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-08-01 EP claimed
JP-1040940-A None JP disclosed
JP-5323550-A None JP disclosed
CN-118339510-A Liquid crystal display device 默克专利股份有限公司 2024-07-12 CN disclosed
US-20240199616-A1 BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2024-06-20 US disclosed
US-4362806-A PHOTOGRAPHY, SILVER HALIDE EMULSIONS EASTMAN KODAK COMPANY (US) 1982-12-07 US disclosed
US-4269927-A DOPED WITH CADMIUM, LEAD, COPPER, OR ZINC OR MIXTURES; HIGH SPEED COLOR FILMS; LOW CONCENTRATION OF SILVER IODIDE EASTMAN KODAK COMPANY (US) 1981-05-26 US disclosed
US-4269914-A INCLUDING A LAYER TO RECEIVE AND IMMOBILIZE A DIFFUSIBLE DESENSITIZER ABLE TO EFFECT THE SENSITIVITY OF A SILVER HALIDE EMULSION TO ELECTROMAGNETIC RADIATION AND A BARRIER LAYER EASTMAN KODAK COMPANY (US) 1981-05-26 US disclosed
EP-0017148-A1 Internally doped high chloride silver halide emulsions, processes for their preparation and photographic elements EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1980-10-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199616-A1 BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS PTPN18, PTPN1, PTPN2 ALDH1A1 4439/4885FKBP5 1246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.