Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 17/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 17/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 17/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719292 | 0.87 | LTA4H (0.42) | S1PR1S1PR3S1PR5DRD2DRD4 | |
| SCHEMBL16719305 | 0.85 | S1PR1 (0.52) | S1PR1S1PR2S1PR3LPAR2S1PR4 | |
| SCHEMBL16719333 | 0.84 | S1PR1 (0.62) | S1PR1S1PR2S1PR3LPAR2 | |
| SCHEMBL16719277 | 0.84 | S1PR1 (0.53) | S1PR1S1PR2S1PR3LPAR2S1PR4 | |
| SCHEMBL16719344 | 0.83 | S1PR1 (0.53) | S1PR1S1PR2S1PR3LPAR2S1PR4 | |
| SCHEMBL16719283 | 0.83 | S1PR1 (0.59) | S1PR1S1PR2S1PR3LPAR2S1PR4 | |
| SCHEMBL16719341 | 0.81 | S1PR1 (0.53) | S1PR1S1PR2S1PR3LPAR2 | |
| SCHEMBL16719378 | 0.81 | S1PR1 (0.50) | S1PR1S1PR2S1PR3LPAR2S1PR4 | |
| SCHEMBL16719318 | 0.78 | S1PR1 (0.52) | S1PR1S1PR2S1PR3LPAR2 | |
| SCHEMBL16728381 | 0.78 | LMNA (0.39) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073556-A1 | DISUBSTITUTED PHENOXY DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-21 | — | — | WO | claimed |
| WO-2015073556-A1 | DISUBSTITUTED PHENOXY DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-21 | — | — | WO | disclosed |