Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 13/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 13/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27625438 | 0.81 | HSD17B1 (0.68) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL27905669 | 0.78 | HSD17B1 (0.63) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL29444135 | 0.76 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL23868941 | 0.76 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL1180643 | 0.76 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL16719539 | 0.76 | HPGDS (0.47) | ESR2 | |
| SCHEMBL27813877 | 0.76 | PRKCI (0.51) | PIK3CDPIK3CA | |
| SCHEMBL4775356 | 0.76 | HSD17B1 (0.56) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL21944933 | 0.74 | HSD17B1 (0.59) | HSD17B1HSD17B2CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL27612450 | 0.74 | NPC1 (0.63) | HSD17B1HSD17B2CYP3A4CYP2C9METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |