Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | RHEB | Q15382 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316190 | 0.87 | ALDH1A1 (0.60) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL694906 | 0.85 | NPC1 (0.62) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL9033788 | 0.82 | NPC1 (0.53) | ALDH1A1KDM4EHPGDHSD17B10RHEB | |
| SCHEMBL695765 | 0.82 | KDM4E (0.61) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL704211 | 0.81 | NPBWR1 (0.51) | — | |
| SCHEMBL2124653 | 0.81 | KDM4E (0.66) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL5543777 | 0.80 | KDM4E (0.37) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL2079577 | 0.80 | RHEB (0.57) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL2078169 | 0.79 | KDM4E (0.38) | ALDH1A1PKN1PKN2KDM4EHPGD | |
| SCHEMBL9032674 | 0.77 | KDM4E (0.63) | ALDH1A1KDM4EHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |