Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 8/20 | 0.39 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27805650 | 0.78 | METAP2 (0.54) | METAP1METAP2KDM4ENPC1TP53 | |
| SCHEMBL16720288 | 0.72 | CLK1 (0.41) | KDM4ENPC1CYP1A2CYP2C19RAB9A | |
| SCHEMBL3706161 | 0.71 | ITK (0.48) | METAP1METAP2KDM4ENPC1RAB9A | |
| SCHEMBL16719904 | 0.71 | METAP1 (0.64) | METAP1METAP2KDM4ENPC1TP53 | |
| SCHEMBL700181 | 0.68 | NPC1 (0.61) | KDM4ENPC1TP53CYP1A2CYP2D6 | |
| SCHEMBL16720322 | 0.66 | CTSV (0.43) | KDM4ENPC1CYP1A2CYP2C19RAB9A | |
| SCHEMBL16720887 | 0.66 | METAP1 (0.42) | METAP1METAP2 | |
| SCHEMBL16720695 | 0.66 | KDM4A (0.34) | METAP1METAP2KDM4ENPC1TP53 | |
| SCHEMBL16720684 | 0.65 | NPC1 (0.37) | METAP1METAP2KDM4ENPC1TP53 | |
| SCHEMBL533869 | 0.64 | METAP1 (0.36) | METAP1METAP2KDM4ENPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |