Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 5/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720495 | 0.88 | TYR (0.46) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL2192638 | 0.80 | NPC1 (0.47) | NPC1USP2GAAALOX15RAD51 | |
| SCHEMBL27500073 | 0.78 | GUSB (0.68) | NPC1USP2GAAALOX15RAD51 | |
| SCHEMBL16719957 | 0.77 | TRPA1 (0.50) | DYRK1ADYRK2DYRK1BARCLK1 | |
| SCHEMBL16720011 | 0.75 | RIPK1 (0.55) | DYRK1ADYRK1BCCNCCDK8 | |
| SCHEMBL732897 | 0.75 | NPC1 (0.67) | NPC1USP2GAAALOX15RAD51 | |
| SCHEMBL16720439 | 0.74 | QPCT (0.50) | ARMAPT | |
| SCHEMBL732779 | 0.73 | NPC1 (0.64) | NPC1USP2GAAALOX15RAD51 | |
| SCHEMBL15510713 | 0.73 | NPC1 (0.46) | NPC1USP2GAAALOX15RAD51 | |
| SCHEMBL12680421 | 0.72 | NPC1 (0.67) | NPC1USP2GAAALOX15RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |