Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720290 | 0.82 | SCN9A (0.36) | CYP1A2METAP2METAP1SCN9ANPC1 | |
| SCHEMBL16719913 | 0.79 | ECE1 (0.39) | ECE1CYP1A2CYP1A1CYP1B1METAP2 | |
| SCHEMBL16720259 | 0.76 | KDM4E (0.34) | CYP1A2METAP2METAP1CYP19A1NPC1 | |
| SCHEMBL2885322 | 0.75 | CA1 (0.50) | SMN1; SMN2KDM4EMAPTCA12CA1 | |
| SCHEMBL16720573 | 0.75 | METAP2 (0.36) | ECE1CYP1A2CYP1A1CYP1B1METAP2 | |
| SCHEMBL4522711 | 0.73 | CYP19A1 (0.51) | METAP2METAP1CYP19A1SCN9ANPC1 | |
| SCHEMBL16720601 | 0.73 | IDO1 (0.33) | CYP1A2METAP2METAP1NPC1RAB9A | |
| SCHEMBL16720102 | 0.72 | MAPT (0.33) | CYP1A2METAP2METAP1NPC1RAB9A | |
| SCHEMBL16719856 | 0.70 | SMN1; SMN2 (0.41) | CYP1A2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6607926 | 0.69 | METAP1 (0.39) | CYP1A2METAP2METAP1SCN9AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |