Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372578 | 0.85 | APP (0.47) | CA1CA2CA7CA9CA12 | |
| SCHEMBL1274782 | 0.85 | CA1 (0.46) | CA1CA2CA7CA9CA12 | |
| SCHEMBL7454339 | 0.82 | CA12 (0.38) | CA1CA2CA7CA9CA12 | |
| SCHEMBL6188780 | 0.82 | CA12 (0.41) | CA1CA2CA7CA9CA12 | |
| SCHEMBL8089505 | 0.82 | CA12 (0.38) | CA1CA2CA7CA9CA12 | |
| SCHEMBL3941441 | 0.80 | RPS6KB2 (0.46) | ALDH1A1TP53MAPK1KDM4ELMNA | |
| SCHEMBL16719856 | 0.80 | SMN1; SMN2 (0.41) | CA1CA2CA7CA9CA12 | |
| SCHEMBL8124307 | 0.80 | CA1 (0.41) | CA1CA2CA7CA9CA12 | |
| SCHEMBL28621595 | 0.80 | ALDH1A1 (0.38) | CA1CA2CA7CA9CA12 | |
| SCHEMBL2027163 | 0.79 | APP (0.46) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114669333-B | Catalyst system and catalytic method for catalyzing decarbonylation hydrogenation of alpha-quaternary carbon aldehyde | 中山大学 | 2023-06-23 | — | — | CN | claimed |
| EP-1078923-B1 | Process for the preparation of benzothiophene derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-08 | — | — | EP | claimed |
| US-6777559-B2 | CYCLOCARBONYLATING ACETIC ACID (OR BENZOIC ACID)-1-(1-BENZENESULFONYL-1H-INDOL-2-YL)-ALLYL ESTER TO OBTAIN 9-BENZENESULFONYL-9H-CARBAZOL-4-YL ESTER; SAPONIFYING | HOFFMANN-LA ROCHE INC. | 2004-08-17 | — | — | US | claimed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | claimed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | claimed |
| US-20020010345-A1 | Methods for the preparation of 4-hydroxy benzothiophene | JUNGHANS BERND (DE) | 2002-01-24 | — | — | US | claimed |
| US-6291685-B1 | REACTING 1-(2-THIENYL)ALLYL DERIVATIVE IN SOLVENT MEDIUM CONTAINING BASE AND CARBOXYLIC ACID ANHYDRIDE WITH CARBON MONOXIDE IN PRESENCE OF CARBONYLATION CATALYST TO FORM ESTER COMPOUND; SAPONIFICATION TO FORM 4-HYDROXYBENZOTHIOPHENE | HOFFMANN-LA ROCHE INC. | 2001-09-18 | — | — | US | claimed |
| EP-1078923-A2 | Process for the preparation of benzothiophene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-28 | — | — | EP | claimed |
| US-5600015-A | USING RUTHENIUM COMPLEX OF OPTICALLY ACTIVE ATROPISOMERIC DIPHOSPHINE LIGAND AS HYDROGENATION CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1997-02-04 | — | — | US | claimed |
| CN-114669333-B | Catalyst system and catalytic method for catalyzing decarbonylation hydrogenation of alpha-quaternary carbon aldehyde | 中山大学 | 2023-06-23 | — | — | CN | disclosed |
| US-7847126-B2 | prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example | LANXESS DEUTSCHLAND GMBH (DE) | 2010-12-07 | — | — | US | disclosed |
| US-20070299273-A1 | prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example | LANXESS DEUTSCHLAND GMBH (DE) | 2007-12-27 | — | — | US | disclosed |
| US-7230136-B2 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2007-06-12 | — | — | US | disclosed |
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-6437144-B2 | CYCLOCARBONYLATION | HOFFMANN-LA ROCHE INC. | 2002-08-20 | — | — | US | disclosed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | disclosed |
| US-20020077488-A1 | Methods for the preparation of 4-hydroxy benzothiophene | JUNGHANS BERND (DE) | 2002-06-20 | — | — | US | disclosed |
| US-20020010345-A1 | Methods for the preparation of 4-hydroxy benzothiophene | JUNGHANS BERND (DE) | 2002-01-24 | — | — | US | disclosed |
| US-6291685-B1 | REACTING 1-(2-THIENYL)ALLYL DERIVATIVE IN SOLVENT MEDIUM CONTAINING BASE AND CARBOXYLIC ACID ANHYDRIDE WITH CARBON MONOXIDE IN PRESENCE OF CARBONYLATION CATALYST TO FORM ESTER COMPOUND; SAPONIFICATION TO FORM 4-HYDROXYBENZOTHIOPHENE | HOFFMANN-LA ROCHE INC. | 2001-09-18 | — | — | US | disclosed |
| EP-1078923-A2 | Process for the preparation of benzothiophene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077488-A1 | Methods for the preparation of 4-hydroxy benzothiophene | SLC5A2, SLC5A1, TST | CA1 3154/4885CA2 881/4885CA7 529/4885 |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | CA1 2292/4885CA2 3190/4885CA7 1108/4885 |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | CA1 2292/4885CA2 3190/4885CA7 1108/4885 |
| US-20020010345-A1 | Methods for the preparation of 4-hydroxy benzothiophene | SLC5A2, TST, SLC5A1 | CA1 1873/4885CA2 624/4885CA7 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.