Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720677 | 0.81 | SCN9A (0.35) | METAP2METAP1SCN9AIDO1TDO2 | |
| SCHEMBL6607926 | 0.79 | METAP1 (0.39) | METAP2METAP1SCN9AIDO1TDO2 | |
| SCHEMBL9044447 | 0.79 | IDO1 (0.36) | METAP2METAP1SCN9AIDO1TDO2 | |
| SCHEMBL16719424 | 0.76 | ECE1 (0.38) | METAP2METAP1ECE1TSHRPDE10A | |
| SCHEMBL16719785 | 0.75 | ECE1 (0.37) | METAP2METAP1SCN9ANPC1RAB9A | |
| SCHEMBL7109285 | 0.74 | — | — | |
| SCHEMBL4522711 | 0.73 | CYP19A1 (0.51) | METAP2METAP1SCN9ANPC1RAB9A | |
| SCHEMBL8205927 | 0.72 | CYP2A6 (0.39) | NPC1CYP3A4CYP2C19 | |
| SCHEMBL7447711 | 0.72 | ALDH1A1 (0.38) | METAP2POLBCYP19A1KDM4ECYP3A4 | |
| SCHEMBL16720204 | 0.72 | KDM4E (0.38) | METAP2METAP1SCN9AIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |