Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720292 | 0.80 | SCN9A (0.34) | NPC1MAPTRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7855621 | 0.79 | TSHR (0.36) | NPC1RAB9ASMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL4522711 | 0.77 | CYP19A1 (0.51) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL16720261 | 0.76 | CASP6 (0.35) | NPC1RAB9ASMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL7508479 | 0.76 | CASP6 (0.35) | NPC1RAB9ASMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL6541679 | 0.75 | CA1 (0.38) | MAPTKDM4E | |
| SCHEMBL6511340 | 0.73 | MAPT (0.41) | NPC1MAPTRAB9ASMN1; SMN2ECE1 | |
| SCHEMBL14754488 | 0.73 | CYP1A1 (0.59) | NPC1MAPTRAB9ASMN1; SMN2CYP1A1 | |
| SCHEMBL16720602 | 0.73 | IDO1 (0.33) | — | |
| SCHEMBL16720103 | 0.72 | CASP6 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |