Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855621 | 0.79 | TSHR (0.36) | KDM4AKDM4BKDM5CKDM5BPOLB | |
| SCHEMBL7508479 | 0.79 | CASP6 (0.35) | CASP6KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL16720103 | 0.79 | CASP6 (0.33) | CASP6KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL16719786 | 0.76 | NPC1 (0.38) | POLBSMN1; SMN2METAP2METAP1KDM4E | |
| SCHEMBL2789458 | 0.74 | CYP19A1 (0.47) | CASP6LMNASMN1; SMN2METAP2METAP1 | |
| SCHEMBL16720602 | 0.73 | IDO1 (0.33) | KDM4AKDM4BKDM5CKDM5BIDO1 | |
| SCHEMBL31718137 | 0.73 | HTT (0.55) | LMNAHSP90AA1HSP90AB1MAPK1HTT | |
| SCHEMBL657801 | 0.73 | HTT (0.55) | LMNAHSP90AA1HSP90AB1MAPK1HTT | |
| SCHEMBL16720292 | 0.71 | SCN9A (0.34) | SMN1; SMN2METAP2METAP1KDM4ENPC1 | |
| SCHEMBL16720809 | 0.70 | KDM4E (0.45) | CASP6LMNAHSP90AA1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |