Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 3/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28426600 | 0.79 | CA12 (0.37) | MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL4173625 | 0.76 | CYP1A2 (0.50) | KDM4EALDH1A1HPGD | |
| SCHEMBL30574690 | 0.75 | GHSR (0.48) | BRD4MEN1POLBMAPK1KMT2A | |
| SCHEMBL2459910 | 0.75 | GHSR (0.48) | BRD4MEN1POLBMAPK1KMT2A | |
| SCHEMBL16766999 | 0.75 | LMNA (0.36) | MEN1POLBMAPK1KMT2A | |
| SCHEMBL4786964 | 0.73 | AHR (0.49) | BRD4AHRCMA1TYRDYRK1B | |
| SCHEMBL28313237 | 0.73 | — | — | |
| SCHEMBL15566769 | 0.72 | AHR (0.52) | BRD4MEN1POLBMAPK1KMT2A | |
| SCHEMBL18000228 | 0.72 | BRAF (0.58) | BRD4AHRCMA1TYRCHRNA7 | |
| SCHEMBL2460991 | 0.71 | BRD4 (0.44) | BRD4MEN1POLBMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1059210-C | Process for preparing 6-heterocyclic-4-amino-1, 3,4, 5-tetrahydrobenz [ cd ] indoles and their pharmaceutically acceptable acid addition salts | LILLY CO ELI (US) | 2000-12-06 | — | — | CN | disclosed |
| CN-1268352-A | Method for preparing medicinal prepns. contg. 6-heterocycle-4-amino-1,3,4,5-tetrabenzo [cd] indole | LILLY CO ELI (US) | 2000-10-04 | — | — | CN | disclosed |
| CN-1056144-C | 6-heterocyclic-4-amino1,3,4,5-tetrahydrobenz{CD}indoles for treating motion sickness and vomiting | LILLY CO ELI (US) | 2000-09-06 | — | — | CN | disclosed |
| CN-1094724-A | 6-heterocycle-4-the amino-1,3,4 that is used for the treatment of motion sickness and vomiting sickness, 5-tetrahydro benzo [cd] indoles | LILLY CO ELI (US) | 1994-11-09 | — | — | CN | disclosed |
| CN-1066071-A | 6-heterocyclic radical-4-amino-1,2,2a, 3,4, the 5-hexahydrobenzene is [cd] indoles also | LILLY CO ELI (US) | 1992-11-11 | — | — | CN | disclosed |
| CN-1066072-A | 6-heterocyclic-4-amino-1, 3, 4, 5-tetrahydrobenzo [ cd ] indoles | LILLY CO ELI (US) | 1992-11-11 | — | — | CN | disclosed |