Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 15/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5702666 | 0.78 | CYP1A1 (0.74) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL16720419 | 0.77 | DYRK1A (0.50) | CYP1A1CYP1B1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16720480 | 0.74 | HSD17B1 (0.41) | CYP11B1CYP11B2CYP3A4CYP17A1 | |
| SCHEMBL30338912 | 0.71 | CYP1A1 (0.63) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL744752 | 0.71 | CYP1A1 (0.61) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL16720028 | 0.70 | ATM (0.36) | — | |
| SCHEMBL21960161 | 0.69 | CYP11B1 (0.73) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL12302844 | 0.68 | CYP11B1 (0.65) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11947382 | 0.67 | CYP1A1 (0.62) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL15296276 | 0.67 | CYP11B1 (0.64) | CYP1A1CYP1B1CYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |