Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958013 | 0.81 | MAPT (0.43) | MAPTLMNARPS6KA3NPC1RAB9A | |
| SCHEMBL16720501 | 0.79 | CYP2A6 (0.48) | MAPTLMNAERN1NPC1RAB9A | |
| SCHEMBL159940 | 0.79 | ALDH1A1 (0.54) | MAPTALDH1A1HSD17B10EGFRKDM4E | |
| SCHEMBL16719637 | 0.79 | ESR1 (0.42) | MAPTLMNARPS6KA3NPC1RAB9A | |
| SCHEMBL16719720 | 0.78 | CYP17A1 (0.36) | ERN1CCNCCDK8 | |
| SCHEMBL16719813 | 0.78 | — | — | |
| SCHEMBL9988102 | 0.76 | BACE1 (0.38) | RPS6KA3NPC1RAB9AALDH1A1HSD17B10 | |
| SCHEMBL6669375 | 0.76 | PIK3CA (0.35) | RPS6KA3NPC1RAB9AALDH1A1HSD17B10 | |
| SCHEMBL16720203 | 0.76 | ALOX5 (0.41) | MAPTLMNANPC1RAB9AHSD17B10 | |
| SCHEMBL27343606 | 0.76 | MAPT (0.39) | MAPTLMNANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |