Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4B | O94953 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719446 | 0.71 | METAP2 (0.33) | LMNAHSP90AA1HSP90AB1HTTMAPK1 | |
| SCHEMBL16720441 | 0.71 | POLB (0.34) | POLBECE1NPC1MET | |
| SCHEMBL16720127 | 0.71 | COMT (0.40) | KDM4ELMNACYP3A4MEN1MAPT | |
| SCHEMBL16719913 | 0.68 | ECE1 (0.39) | POLBECE1KDM4ELMNACYP3A4 | |
| SCHEMBL16720142 | 0.67 | BACE1 (0.46) | POLBKDM4ELMNACYP3A4HTT | |
| SCHEMBL16720259 | 0.67 | KDM4E (0.34) | POLBKDM4ELMNACYP3A4HSP90AA1 | |
| SCHEMBL16719291 | 0.67 | POLB (0.41) | POLBECE1NPC1KDM4AKDM4B | |
| SCHEMBL16056542 | 0.66 | CYP3A4 (0.48) | KDM4ELMNACYP3A4MEN1MAPT | |
| SCHEMBL16720486 | 0.66 | KDM4E (0.42) | POLBECE1KDM4ELMNANPSR1 | |
| SCHEMBL28243375 | 0.65 | POLB (0.45) | POLBECE1KDM4ELMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |