Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719448 | 0.76 | LMNA (0.33) | KDM4EPOLBLMNASMN1; SMN2MAPT | |
| SCHEMBL16719786 | 0.71 | NPC1 (0.38) | KDM4EPOLBECE1CYP1A1CYP1A2 | |
| SCHEMBL28243375 | 0.69 | POLB (0.45) | KDM4EPOLBECE1CYP1A1CYP1A2 | |
| SCHEMBL26260070 | 0.69 | CYP1A1 (0.45) | KDM4EPOLBECE1CYP1A1CYP1A2 | |
| SCHEMBL2502094 | 0.66 | CYP3A4 (0.44) | KDM4ECYP1A2LMNASMN1; SMN2MAPT | |
| SCHEMBL16720145 | 0.66 | PDE4B (0.46) | KDM4ELMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL16719913 | 0.66 | ECE1 (0.39) | KDM4EPOLBECE1CYP1A1CYP1A2 | |
| SCHEMBL16720484 | 0.66 | POLB (0.45) | KDM4EPOLBECE1CYP1A1CYP1A2 | |
| SCHEMBL16720261 | 0.65 | CASP6 (0.35) | KDM4EPOLBCYP1A2LMNASMN1; SMN2 | |
| SCHEMBL1494184 | 0.64 | KDM4E (0.40) | KDM4EPOLBECE1CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |