Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720142 | 0.83 | BACE1 (0.46) | KDM4EUSP2CYP1A2CYP3A4NPC1 | |
| SCHEMBL16720488 | 0.77 | ABL1 (0.41) | CYP1A2CYP1A1CYP1B1CYP3A4NPC1 | |
| SCHEMBL16719944 | 0.74 | ESR2 (0.44) | KDM4ENPC1SMN1; SMN2MAPK1RAB9A | |
| SCHEMBL16720484 | 0.71 | POLB (0.45) | KDM4ECYP1A2CYP1A1CYP1B1CYP3A4 | |
| SCHEMBL16720143 | 0.70 | MEN1 (0.51) | CYP1A1CYP1B1MAPK1ABL1ABCB1 | |
| SCHEMBL16056542 | 0.69 | CYP3A4 (0.48) | KDM4EUSP2CYP1A1CYP1B1ERN1 | |
| SCHEMBL16720516 | 0.68 | QDPR (0.36) | KDM4EPDGFRBPDGFRAQDPRCYP1A2 | |
| SCHEMBL16720650 | 0.68 | QDPR (0.36) | PDGFRBPDGFRAQDPRERN1CYP3A4 | |
| SCHEMBL27934853 | 0.67 | CYP3A4 (0.46) | KDM4EUSP2CYP1A1CYP1B1ERN1 | |
| SCHEMBL16720286 | 0.67 | PDGFRB (0.42) | KDM4EUSP2PDGFRBPDGFRACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |