Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4B | O94953 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719353 | 0.89 | METAP2 (0.40) | METAP2METAP1TDP2KDM4AKDM4B | |
| SCHEMBL16720610 | 0.75 | NAMPT (0.39) | — | |
| SCHEMBL694855 | 0.73 | L3MBTL1 (0.49) | — | |
| SCHEMBL694531 | 0.71 | MAPK14 (0.40) | — | |
| SCHEMBL16719735 | 0.70 | METAP1 (0.42) | METAP2METAP1TDP2 | |
| SCHEMBL3483035 | 0.70 | ADORA2A (0.48) | — | |
| SCHEMBL2563733 | 0.68 | GSK3B (0.34) | — | |
| SCHEMBL3483049 | 0.68 | ESR1 (0.33) | — | |
| SCHEMBL15516454 | 0.68 | CCR4 (0.31) | — | |
| SCHEMBL16720887 | 0.68 | METAP1 (0.42) | METAP2METAP1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |