Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672243 | 0.91 | SIGMAR1 (0.38) | MEN1KMT2AHTR3AATMCHRNA7 | |
| SCHEMBL1672396 | 0.90 | GAA (0.35) | GAAMEN1KMT2ASMN1; SMN2HTR3A | |
| SCHEMBL1673270 | 0.88 | GAA (0.38) | GAAMEN1KMT2ASMN1; SMN2CHRNA7 | |
| SCHEMBL1672246 | 0.86 | GAA (0.36) | GAAMEN1KMT2ASMN1; SMN2HTR3A | |
| SCHEMBL1673275 | 0.85 | GAA (0.32) | GAAMEN1KMT2ASMN1; SMN2HTR3A | |
| SCHEMBL4322855 | 0.83 | HTR3A (0.43) | GAAHTR3A | |
| SCHEMBL4311857 | 0.83 | HTR3A (0.43) | GAAHTR3A | |
| SCHEMBL4311862 | 0.83 | HTR3A (0.43) | GAAHTR3A | |
| SCHEMBL699992 | 0.83 | HTR3A (0.42) | GAAHTR3A | |
| SCHEMBL1672707 | 0.83 | MEN1 (0.47) | GAAMEN1KMT2ASMN1; SMN2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310019-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009155054-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |