Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672705 | 0.91 | SIGMAR1 (0.37) | HTR3ACHRNA7ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1673270 | 0.87 | GAA (0.38) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL1672396 | 0.87 | GAA (0.35) | GAASMN1; SMN2MEN1KMT2AHTR3A | |
| SCHEMBL1672241 | 0.86 | GAA (0.37) | GAASMN1; SMN2MEN1KMT2AHTR3A | |
| SCHEMBL701669 | 0.84 | HTR3A (0.42) | GAAHTR3A | |
| SCHEMBL4311850 | 0.84 | HTR3A (0.42) | GAAHTR3A | |
| SCHEMBL701670 | 0.84 | HTR3A (0.42) | GAAHTR3A | |
| SCHEMBL700430 | 0.83 | HTR3A (0.42) | GAAHTR3ACYP1A2CYP2C9 | |
| SCHEMBL1672707 | 0.82 | MEN1 (0.47) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL1673275 | 0.79 | GAA (0.32) | GAASMN1; SMN2MEN1KMT2AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310019-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009155054-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |