SCHEMBL1672248

SCHEMBL1672248

Cc1ccc2c(c(CCNC3CN4CCC3CC4)nn2Cc2ccccc2)c1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.40
HTR3A P46098 2/20 0.39
POLB P06746 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CHRNA7 P36544 2/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
HTT P42858 1/20 0.35
GAA P10253 1/20 0.35
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1672243 0.89 SIGMAR1 (0.38) SIGMAR1HTR3AMEN1KMT2ACHRNA7
SCHEMBL1672448 0.86 SIGMAR1 (0.39) SIGMAR1HTR3ACHRNA7HTR3EHTR3B
SCHEMBL4328332 0.85 HTR3A (0.45) SIGMAR1HTR3ACHRNA7
SCHEMBL699893 0.85 HTR3A (0.45) SIGMAR1HTR3ACHRNA7
SCHEMBL699894 0.85 HTR3A (0.45) SIGMAR1HTR3ACHRNA7
SCHEMBL701116 0.84 HTR3A (0.44) SIGMAR1HTR3ACHRNA7
SCHEMBL1672705 0.83 SIGMAR1 (0.37) SIGMAR1HTR3ACHRNA7
SCHEMBL700054 0.82 HTR3A (0.42) SIGMAR1HTR3ACHRM2CHRM1CHRM3
SCHEMBL701557 0.82 HTR3A (0.42) SIGMAR1HTR3ACHRM2CHRM1CHRM3
SCHEMBL700053 0.82 HTR3A (0.42) SIGMAR1HTR3ACHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2310019-A2 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF Albany Molecular Research, Inc. (US) 2011-04-20 EP disclosed
WO-2009155054-A2 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2009-12-23 WO disclosed