Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.32 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672283 | 1.00 | ESR1 (0.32) | ESR1KDM1AESR2SENP1HSD11B1 | |
| SCHEMBL1671213 | 0.85 | NTRK1 (0.38) | USP7 | |
| SCHEMBL1670618 | 0.84 | — | — | |
| SCHEMBL1670617 | 0.84 | — | — | |
| SCHEMBL1670636 | 0.81 | USP7 (0.30) | USP7 | |
| SCHEMBL1670319 | 0.80 | SENP1 (0.30) | SENP1 | |
| SCHEMBL1670523 | 0.80 | SENP1 (0.30) | SENP1 | |
| SCHEMBL1672287 | 0.79 | ESR1 (0.32) | ESR1ESR2SENP1 | |
| SCHEMBL1672901 | 0.77 | IDO1 (0.36) | — | |
| SCHEMBL1670635 | 0.76 | PTPN1 (0.34) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |