Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672805 | 1.00 | BRD4 (0.38) | BRD4BRD2MLYCDERN1HSP90AB1 | |
| SCHEMBL1672861 | 0.91 | BRD4 (0.38) | BRD4BRD2MLYCDERN1CREBBP | |
| SCHEMBL1672863 | 0.91 | BRD4 (0.38) | BRD4BRD2MLYCDERN1CREBBP | |
| SCHEMBL12800384 | 0.86 | BRD4 (0.39) | BRD4BRD2MLYCDERN1HSP90AB1 | |
| SCHEMBL1672789 | 0.85 | ERN1 (0.38) | BRD4BRD2MLYCDERN1 | |
| SCHEMBL1672787 | 0.85 | ERN1 (0.38) | BRD4BRD2MLYCDERN1 | |
| SCHEMBL1670718 | 0.84 | TLR8 (0.41) | BRD4BRD2MLYCDCREBBP | |
| SCHEMBL1670714 | 0.84 | TLR8 (0.41) | BRD4BRD2MLYCDCREBBP | |
| SCHEMBL1670492 | 0.84 | BRD4 (0.35) | BRD4ERN1HSP90AB1CREBBPAR | |
| SCHEMBL1670734 | 0.81 | MLYCD (0.38) | BRD4BRD2MLYCDERN1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |