Sugi Predict

Sugi Predict / Compounds / SCHEMBL1672831

SCHEMBL1672831

SCHEMBL1672831

COCc1nn2cc(C(F)(F)F)nc2s1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 5/20 0.54
▸ MAPT P10636 4/20 0.54
▸ SMN1; SMN2 Q16637 3/20 0.54
▸ F2RL3 Q96RI0 10/20 0.39
▸ NPC1 O15118 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ ALPL P05186 2/20 0.34
▸ ALPI P09923 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1671682 0.86 TP53 (0.40) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL12690055 0.86 TP53 (0.40) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL20642850 0.82 TP53 (0.37) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL1671679 0.80 TP53 (0.58) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL21138063 0.80 TP53 (0.65) TP53MAPTSMN1; SMN2NPC1PKM
SCHEMBL1672605 0.79 TP53 (0.40) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL12689937 0.78 TP53 (0.35) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL1672156 0.77 TP53 (0.54) TP53MAPTSMN1; SMN2F2RL3NPC1
SCHEMBL23415150 0.75 ALPL (0.58) ALPLALPI
SCHEMBL21550398 0.73 TP53 (0.51) TP53MAPTSMN1; SMN2F2RL3NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112088160-B 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives UCB生物制药有限责任公司 2023-07-04 — — CN disclosed
EP-3790885-B1 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES UCB Biopharma SRL (BE) 2023-04-19 — — EP disclosed
CN-110869374-B 2-oxo-1, 3-oxazolidinyl imidazothiadiazole derivatives UCB生物制药有限责任公司 2022-08-30 — — CN disclosed
US-11286266-B2 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives UCB Biopharma SRL 2022-03-29 — — US disclosed
US-11155565-B2 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives UCB Biopharma SRL 2021-10-26 — — US disclosed
EP-3652183-B1 2-OXO-1,3-OXAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES UCB Biopharma SRL (BE) 2021-09-08 — — EP disclosed
US-20210107922-A1 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) 2021-04-15 — — US disclosed
EP-3790885-A1 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES UCB Biopharma SRL (BE) 2021-03-17 — — EP disclosed
US-20200231599-A1 2-OXO-1,3-OXAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES UCB BIOPHARMA SPRL (BE) 2020-07-23 — — US disclosed
WO-2019215062-A1 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES UCB BIOPHARMA SPRL (BE) 2019-11-14 — — WO disclosed
US-8822508-B2 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives UCB PHARMA, S.A. (BE) 2014-09-02 — — US disclosed
US-20140148489-A1 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2014-05-29 — — US disclosed
US-20140148489-A1 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2014-05-29 — — US disclosed
US-20140148489-A1 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2014-05-29 — — US disclosed
US-20120245208-A1 2-Oxo-1-Pyrrolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2012-09-27 — — US disclosed
US-20120245208-A1 2-Oxo-1-Pyrrolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2012-09-27 — — US disclosed
US-20120245208-A1 2-Oxo-1-Pyrrolidinyl Imidazothiadiazole Derivatives UCB PHARMA, S.A. (BE) 2012-09-27 — — US disclosed
EP-2491045-A1 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES UCB Pharma S.A. (BE) 2012-08-29 — — EP disclosed
WO-2011047860-A1 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES UCB PHARMA, S.A. (BE) 2011-04-28 — — WO disclosed
WO-2011047860-A1 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES UCB PHARMA, S.A. (BE) 2011-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11155565-B2 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives CYP3A43, CYP3A4, CYP3A7 TP53 3658/4885MAPT 2052/4885SMN1; SMN2 2340/4885
US-20140148489-A1 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives CYP3A4, CYP3A43, CYP3A7 TP53 2654/4885MAPT 956/4885SMN1; SMN2 2264/4885
US-11286266-B2 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives TPMT, THPO, PKD1 TP53 2196/4885MAPT 570/4885SMN1; SMN2 2243/4885
US-20200231599-A1 2-OXO-1,3-OXAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES CYP3A43, CYP3A4, CYP3A7 TP53 3658/4885MAPT 2052/4885SMN1; SMN2 2340/4885
US-20210107922-A1 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES TPMT, THPO, PKD1 TP53 2196/4885MAPT 570/4885SMN1; SMN2 2243/4885
US-20120245208-A1 2-Oxo-1-Pyrrolidinyl Imidazothiadiazole Derivatives CYP3A4, CYP3A43, CYP3A7 TP53 2687/4885MAPT 1016/4885SMN1; SMN2 2662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.