Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1671679 | 0.83 | TP53 (0.58) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL1672831 | 0.80 | TP53 (0.54) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL1672156 | 0.80 | TP53 (0.54) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL21550398 | 0.76 | TP53 (0.51) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL21760985 | 0.73 | MAPT (0.64) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL15605672 | 0.71 | TP53 (0.58) | TP53MAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL452295 | 0.70 | F2RL3 (0.46) | TP53SMN1; SMN2NPC1ALOX15RAB9A | |
| SCHEMBL23585406 | 0.68 | ALDH1A1 (0.41) | TP53MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1671681 | 0.67 | MAPT (0.39) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL21760987 | 0.66 | ALDH1A1 (0.41) | MAPTSMN1; SMN2NPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088160-B | 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives | UCB生物制药有限责任公司 | 2023-07-04 | — | — | CN | disclosed |
| EP-3790885-B1 | 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES | UCB Biopharma SRL (BE) | 2023-04-19 | — | — | EP | disclosed |
| US-11286266-B2 | 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives | UCB Biopharma SRL | 2022-03-29 | — | — | US | disclosed |
| EP-3724198-B1 | 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB Biopharma SRL (BE) | 2022-02-16 | — | — | EP | disclosed |
| US-11155566-B2 | 2-OXO-1-pyrrolidinyl imidazothiadiazole derivatives | UCB Biopharma SRL | 2021-10-26 | — | — | US | disclosed |
| US-20210107922-A1 | 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2021-04-15 | — | — | US | disclosed |
| US-20200399288-A1 | 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2020-12-24 | — | — | US | disclosed |
| WO-2019215062-A1 | 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-11-14 | — | — | WO | disclosed |
| WO-2019115292-A1 | 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399288-A1 | 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | CYP3A4, CYP3A43, CYP3A7 | TP53 2550/4885MAPT 977/4885SMN1; SMN2 2945/4885 |
| US-11155566-B2 | 2-OXO-1-pyrrolidinyl imidazothiadiazole derivatives | CYP3A4, CYP3A43, CYP3A7 | TP53 2550/4885MAPT 977/4885SMN1; SMN2 2945/4885 |
| US-11286266-B2 | 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives | TPMT, THPO, PKD1 | TP53 2196/4885MAPT 570/4885SMN1; SMN2 2243/4885 |
| US-20210107922-A1 | 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES | TPMT, THPO, PKD1 | TP53 2196/4885MAPT 570/4885SMN1; SMN2 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.