Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.32 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.32 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16728764 | 0.91 | CSNK1E (0.51) | CSNK1DCSNK1ERIPK2 | |
| SCHEMBL16711359 | 0.79 | CSNK1E (0.63) | CSNK1DCSNK1ERIPK2 | |
| SCHEMBL16730918 | 0.76 | CSNK1E (0.58) | CSNK1DCSNK1E | |
| SCHEMBL16728629 | 0.75 | CSNK1E (0.44) | CSNK1DCSNK1E | |
| SCHEMBL16730616 | 0.75 | CSNK1E (0.56) | CSNK1DCSNK1E | |
| SCHEMBL16728558 | 0.71 | CSNK1E (0.44) | CSNK1DCSNK1E | |
| SCHEMBL16728621 | 0.71 | CSNK1E (0.36) | CSNK1DCSNK1E | |
| SCHEMBL16730913 | 0.71 | CSNK1E (0.42) | CSNK1DCSNK1ERIPK2ALDH1A1 | |
| SCHEMBL16730675 | 0.69 | CSNK1E (0.51) | CSNK1DCSNK1ERIPK2ALDH1A1 | |
| SCHEMBL16730609 | 0.69 | RIPK2 (0.38) | CSNK1DCSNK1ECACNB4CACNA1ACACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073767-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |