Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786293 | 0.91 | ALDH1A1 (0.47) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL2172048 | 0.91 | ALDH1A1 (0.47) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL2786112 | 0.91 | AURKA (0.43) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL2172237 | 0.91 | AURKA (0.43) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL1614322 | 0.89 | MAPT (0.47) | AURKAMTORKMT2AMEN1ALDH1A1 | |
| SCHEMBL2785875 | 0.88 | MEN1 (0.43) | AURKAMTORKMT2AMEN1ALDH1A1 | |
| SCHEMBL2785880 | 0.88 | MEN1 (0.43) | AURKAMTORKMT2AMEN1ALDH1A1 | |
| SCHEMBL1670279 | 0.88 | AURKA (0.50) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL1614599 | 0.88 | AURKA (0.50) | BCL2AURKAMTORKMT2AMEN1 | |
| SCHEMBL2174333 | 0.88 | KMT2A (0.46) | AURKAMTORKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488027-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | The Ohio State University Research Foundation (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | claimed |