Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172237 | 1.00 | AURKA (0.43) | AURKAMTORCES1PRKAG1PRKAA1 | |
| SCHEMBL2172048 | 0.92 | ALDH1A1 (0.47) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL2786293 | 0.92 | ALDH1A1 (0.47) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL1672882 | 0.91 | BCL2 (0.45) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL1614322 | 0.89 | MAPT (0.47) | AURKAMTORHDAC1PLAUHPN | |
| SCHEMBL1670279 | 0.88 | AURKA (0.50) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL1614599 | 0.88 | AURKA (0.50) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL2785877 | 0.88 | MEN1 (0.43) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL2785875 | 0.88 | MEN1 (0.43) | AURKAMTORPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL2785880 | 0.88 | MEN1 (0.43) | AURKAMTORPRKAG1PRKAA1PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254576-A1 | ANDROGEN RECEPTOT-ABLATIVE AGENTS | The Ohio State University Research Foundation (US) | 2010-12-01 | — | — | EP | claimed |
| WO-2009105621-A1 | ANDROGEN RECEPTOT-ABLATIVE AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-08-27 | — | — | WO | claimed |