Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718883 | 0.85 | ALDH1A1 (0.43) | JAK2JAK1ALDH1A1TSHRGRM5 | |
| SCHEMBL16718807 | 0.82 | JAK2 (0.45) | JAK2JAK1ALDH1A1TSHRPIK3CD | |
| SCHEMBL16718795 | 0.81 | JAK2 (0.47) | JAK2JAK1ALDH1A1TSHRPIK3CD | |
| SCHEMBL16718808 | 0.79 | ATR (0.47) | JAK2JAK1ALDH1A1TSHRPIK3CD | |
| SCHEMBL16729330 | 0.76 | JAK3 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL16729327 | 0.74 | KDM4E (0.47) | JAK2JAK1ALDH1A1TSHRPIK3CD | |
| SCHEMBL17657815 | 0.73 | PIK3CG (0.49) | JAK2JAK1PIK3CDPIK3CGPIK3R2 | |
| SCHEMBL16718875 | 0.73 | KDM4E (0.44) | JAK2JAK1PIK3CDPIK3CGJAK3 | |
| SCHEMBL16729261 | 0.72 | JAK2 (0.44) | JAK2JAK1PIK3CDPIK3CGJAK3 | |
| SCHEMBL16729253 | 0.70 | JAK2 (0.46) | JAK2JAK1PIK3CDPIK3CGJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |