Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.45 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.44 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718874 | 0.90 | GRM4 (0.48) | PIK3CAMTORKMT2AGRM4CHRM4 | |
| SCHEMBL1345454 | 0.86 | JAK2 (0.55) | PIK3CAMTORCHRM4JAK3DPP4 | |
| SCHEMBL21522253 | 0.85 | JAK3 (0.66) | KMT2ASYKJAK3BTKRET | |
| SCHEMBL26292029 | 0.84 | MAP4K4 (0.61) | KMT2AGRM4CHRM4JAK3BTK | |
| SCHEMBL4212961 | 0.82 | DPP4 (0.52) | GRM4CHRM4JAK3DPP4JAK2 | |
| SCHEMBL5216841 | 0.82 | DPP4 (0.52) | GRM4CHRM4JAK3DPP4JAK2 | |
| SCHEMBL952010 | 0.78 | JAK3 (0.58) | SYKJAK3BTKDPP4RET | |
| SCHEMBL29462081 | 0.78 | RET (0.48) | CHRM4JAK3DPP4SMPD3RET | |
| SCHEMBL4008763 | 0.78 | HSD11B1 (0.46) | KMT2AGRM4CHRM4DPP4RET | |
| SCHEMBL4151350 | 0.78 | HSD11B1 (0.46) | KMT2AGRM4CHRM4DPP4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289495-A1 | COMPOUNDS AND METHODS | XDH, CCNY, TOP2B | PIK3CA 3473/4885MTOR 4044/4885KMT2A 2762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.