Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16729369 | 0.86 | HTR1D (0.45) | KIF11SCN9ASCN5AMAP3K5PDE2A | |
| SCHEMBL26144296 | 0.85 | HTR1D (0.47) | KIF11SCN9AMAP3K5MAPTKDM4E | |
| SCHEMBL18580527 | 0.81 | KIF11 (0.50) | KIF11SCN9ASCN5AMAP3K5GSK3B | |
| SCHEMBL13806219 | 0.81 | KIF11 (0.50) | KIF11SCN9ASCN5AGSK3BKDM4E | |
| SCHEMBL16729372 | 0.79 | KIF11 (0.45) | KIF11MAP3K5PDE2AMAPTKDM4E | |
| SCHEMBL15723828 | 0.78 | KIF11 (0.47) | KIF11SCN9ASCN5AGSK3BPDE2A | |
| SCHEMBL27856537 | 0.78 | KIF11 (0.44) | KIF11SCN9ASCN5AGSK3BKDM4E | |
| SCHEMBL30262287 | 0.76 | KIF11 (0.41) | KIF11KDM4E | |
| SCHEMBL2984752 | 0.76 | KIF11 (0.42) | KIF11SCN9ASCN5AMAPTALDH1A1 | |
| SCHEMBL29644294 | 0.76 | ALDH1A1 (0.47) | KIF11SCN9ASCN5AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-9181245-B2 | Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease | Janssen Pharmaceuticals, Inc. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150141411-A1 | SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES USEFUL FOR THE TREATMENT OF (INTER ALIA) ALZHEIMER'S DISEASE | CELLZOME LIMITED (GB) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KIF11 3599/4885SCN9A 3614/4885SCN5A 3194/4885 |
| US-20150141411-A1 | SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES USEFUL FOR THE TREATMENT OF (INTER ALIA) ALZHEIMER'S DISEASE | BACE1, PSEN1, BACE2 | KIF11 4135/4885SCN9A 3175/4885SCN5A 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.