Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204803 | 0.83 | CHRM1 (0.39) | MAPTDGAT1SOAT1HDAC1ALDH1A1 | |
| SCHEMBL206513 | 0.79 | DGAT1 (0.46) | MAPTCA1CA2PNMTDGAT1 | |
| SCHEMBL31095736 | 0.77 | DGAT1 (0.39) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL16407785 | 0.77 | MAPT (0.39) | MAPTPNMTDGAT1SOAT1HDAC1 | |
| SCHEMBL31095821 | 0.77 | MAPT (0.42) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL206706 | 0.75 | GSK3B (0.40) | MAPTPNMTDGAT1SOAT1HDAC1 | |
| SCHEMBL13132751 | 0.73 | MAPT (0.39) | MAPTPNMTDGAT1SOAT1HDAC1 | |
| SCHEMBL13132754 | 0.73 | MEN1 (0.37) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL20788448 | 0.69 | HSD11B1 (0.36) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL22034382 | 0.68 | RAB9A (0.43) | MAPTHDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |