Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.76 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.70 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.70 |
| ▸ | RORA | P35398 | 3/20 | 0.70 |
| ▸ | RORB | Q92753 | 3/20 | 0.70 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | RXRA | P19793 | 1/20 | 0.70 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.70 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.70 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.70 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.70 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.70 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.70 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.70 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.70 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16731518 | 0.89 | RORC (0.81) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL7016049 | 0.88 | RORC (0.76) | RORCNR1H2NR1I2NR1H3RORA | |
| T091317 SCHEMBL457231 | 0.82 | RORC (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14732110 | 0.82 | RORC (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14732184 | 0.81 | RORC (0.77) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL7022970 | 0.79 | NR1H2 (0.71) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL16063605 | 0.76 | RORC (0.86) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL2762946 | 0.75 | NR1H3 (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14300433 | 0.75 | NR1H2 (0.71) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL2944180 | 0.73 | RORC (0.56) | RORCNR1H2NR1I2NR1H3RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003106435-A1 | FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF | SANKYO COMPANY, LIMITED (JP) | 2003-12-24 | — | — | WO | disclosed |