Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070653 | 0.84 | MAPT (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19THPO | |
| SCHEMBL5004485 | 0.83 | ALDH1A1 (0.48) | CYP1A2NPC1RAB9AALDH1A1ALOX15 | |
| SCHEMBL69321 | 0.82 | ALDH1A1 (0.62) | NPC1RAB9ABLMALDH1A1ALOX15 | |
| SCHEMBL29409566 | 0.82 | ALDH1A1 (0.62) | NPC1RAB9ABLMALDH1A1ALOX15 | |
| SCHEMBL10810743 | 0.79 | KDM4E (0.45) | CYP1A2CYP3A4CYP2C9CYP2C19NPC1 | |
| SCHEMBL11001393 | 0.78 | RECQL (0.46) | CYP1A2CYP3A4CYP2C9CYP2C19THPO | |
| SCHEMBL31244095 | 0.77 | ALDH1A1 (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19THPO | |
| SCHEMBL31244311 | 0.77 | ALDH1A1 (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19THPO | |
| SCHEMBL6447254 | 0.77 | CYP2C19 (0.61) | CYP1A2CYP3A4CYP2C9CYP2C19THPO | |
| SCHEMBL31367848 | 0.77 | CA9 (0.50) | NPC1RAB9AALDH1A1ALOX15CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214691-B1 | COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY | UNIV INDIANA RES & TECH CORP (US) | 2015-09-30 | — | — | EP | disclosed |
| US-8980830-B2 | Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20110098217-A1 | COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2011-04-28 | — | — | US | disclosed |
| EP-2214691-A1 | COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY | Indiana University Research and Technology Corporation (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009058734-A1 | COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098217-A1 | COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY | GLP1R, GIPR, GCGR | CYP1A2 4648/4885CYP3A4 4718/4885CYP2C9 4695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.