Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673393 | 0.84 | CYP1A2 (0.48) | MAPTAKR1C3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16994140 | 0.83 | AKR1C3 (0.47) | MAPTGAAAKR1C3NPC1RAB9A | |
| SCHEMBL11000365 | 0.82 | GABRP (0.51) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11001393 | 0.81 | RECQL (0.46) | GAACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29855934 | 0.77 | NPC1 (0.66) | MAPTGAAAKR1C3CYP1A2CYP3A4 | |
| SCHEMBL4444737 | 0.77 | NPC1 (0.66) | MAPTGAAAKR1C3CYP1A2CYP3A4 | |
| SCHEMBL11068446 | 0.75 | CA12 (0.43) | MAPTGAAAKR1C3CYP1A2CYP2C9 | |
| SCHEMBL16796019 | 0.75 | AKR1C3 (0.48) | MAPTGAAAKR1C3NPC1RAB9A | |
| SCHEMBL64069 | 0.74 | AKR1C3 (0.57) | MAPTGAAAKR1C3CYP2C9ALDH1A1 | |
| SCHEMBL1331831 | 0.74 | AKR1C3 (0.57) | MAPTGAAAKR1C3CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4469633-A | N-oxides of 5-oxo-1-phenyl-2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1984-09-04 | — | — | US | disclosed |
| US-4394311-A | Production of 2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1983-07-19 | — | — | US | disclosed |
| US-4388239-A | Production of 1-halophenyl and 1-phenyl-3,4-dihydro-5H-2-benzazepine-5-ones | HOFFMANN-LA ROCHE INC. (US) | 1983-06-14 | — | — | US | disclosed |
| US-4379090-A | Process for the preparation of 1-(phenyl and halophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]5H-2-benzazepin-5-one-2-oxides | HOFFMANN-LA ROCHE INC. (US) | 1983-04-05 | — | — | US | disclosed |
| US-4318854-A | Intermediates in the production of 2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-03-09 | — | — | US | disclosed |