Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735575 | 0.88 | HSP90AA1 (0.58) | PDK1HSP90AA1PDK2PDK3PDK4 | |
| SCHEMBL16735648 | 0.85 | HSP90AA1 (0.43) | PDK1HSP90AA1TP53RECQLRAB9A | |
| SCHEMBL16735621 | 0.83 | TP53 (0.43) | PDK1HSP90AA1TP53RECQLRAB9A | |
| SCHEMBL16735638 | 0.80 | MAOB (0.47) | PDK1HSP90AA1PDK2TP53RECQL | |
| SCHEMBL16735657 | 0.79 | PDK1 (0.49) | PDK1HSP90AA1PDK2PDK3PDK4 | |
| SCHEMBL16735660 | 0.78 | L3MBTL1 (0.54) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735588 | 0.78 | HSP90AA1 (0.52) | PDK1HSP90AA1PDK2PDK3PDK4 | |
| SCHEMBL16735599 | 0.78 | PDK1 (0.51) | PDK1HSP90AA1PDK2PDK3PDK4 | |
| SCHEMBL16735641 | 0.78 | PDK1 (0.51) | PDK1HSP90AA1PDK2PDK3PDK4 | |
| SCHEMBL2143770 | 0.78 | EGLN1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |