Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | RARG | P13631 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955220 | 0.77 | RARB (0.64) | SMN1; SMN2KDM4ERARARARBRARG | |
| SCHEMBL10955224 | 0.77 | RARB (0.64) | SMN1; SMN2KDM4ERARARARBRARG | |
| SCHEMBL24184513 | 0.76 | KDM4E (0.42) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL16661511 | 0.76 | ITGB2 (0.37) | SMN1; SMN2GAARARARARBRARG | |
| SCHEMBL4849393 | 0.73 | ITGB2 (0.37) | SMN1; SMN2RARARARBRARGLMNA | |
| SCHEMBL31583243 | 0.73 | ITGB2 (0.37) | SMN1; SMN2RARARARBRARGLMNA | |
| SCHEMBL637323 | 0.73 | CTNNB1 (0.55) | SMN1; SMN2GAAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL31583563 | 0.72 | RARA (0.36) | SMN1; SMN2GAAKDM4ERARARARB | |
| SCHEMBL583934 | 0.71 | MTNR1B (0.45) | SMN1; SMN2GAAKDM4EMTNR1A | |
| SCHEMBL31582880 | 0.69 | RXRA (0.39) | SMN1; SMN2GAAALDH1A1MTNR1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-B1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LTD (IN) | 2015-05-27 | — | — | EP | disclosed |