Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 1/20 | 0.50 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.50 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27988469 | 0.89 | FFAR4 (0.43) | SLC16A3SLC16A1MCTS1FFAR4GRM2 | |
| SCHEMBL16738426 | 0.88 | FFAR4 (0.43) | SLC16A3SLC16A1MCTS1FFAR4GRM2 | |
| SCHEMBL15057940 | 0.87 | GRM2 (0.41) | SLC16A3SLC16A1MCTS1FFAR4GRM2 | |
| SCHEMBL16738504 | 0.84 | FFAR4 (0.40) | SLC16A3SLC16A1MCTS1FFAR4GRM2 | |
| SCHEMBL27988790 | 0.84 | FFAR4 (0.42) | SLC16A3SLC16A1MCTS1FFAR4GRM2 | |
| SCHEMBL27988474 | 0.75 | FFAR4 (0.36) | FFAR4GRM2GRM3TDP1ALKBH1 | |
| SCHEMBL15054206 | 0.74 | FFAR4 (0.38) | FFAR4GRM2GRM3ALKBH1S1PR1 | |
| SCHEMBL15057599 | 0.73 | GPBAR1 (0.45) | SLC16A3SLC16A1MCTS1FFAR4ALDH1A1 | |
| SCHEMBL27988791 | 0.73 | FFAR4 (0.35) | FFAR4GRM2GRM3TDP1ALKBH1 | |
| SCHEMBL25400027 | 0.69 | L3MBTL1 (0.44) | GRM2GRM3TDP1ALKBH1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | GLP1R, GPR119, TRHR | SLC16A3 462/4885SLC16A1 357/4885MCTS1 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.