Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 9/20 | 0.67 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738642 | 1.00 | UCHL1 (0.67) | UCHL1USP30ALDH1A1TSHRPOLB | |
| SCHEMBL20370276 | 0.94 | UCHL1 (0.72) | UCHL1USP30ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29476005 | 0.82 | NOTUM (0.63) | ALDH1A1TSHRPOLBNOTUMSMN1; SMN2 | |
| SCHEMBL3127747 | 0.82 | NOTUM (0.63) | ALDH1A1TSHRPOLBNOTUMSMN1; SMN2 | |
| SCHEMBL26256077 | 0.81 | STAT6 (0.57) | UCHL1ALDH1A1TSHRPOLBNOTUM | |
| SCHEMBL18387574 | 0.81 | UCHL1 (1.00) | UCHL1USP30HSD17B10HSD11B1 | |
| SCHEMBL18387575 | 0.81 | UCHL1 (1.00) | UCHL1USP30HSD17B10HSD11B1 | |
| SCHEMBL1271972 | 0.79 | UCHL1 (0.53) | UCHL1USP30ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29561144 | 0.79 | UCHL1 (0.75) | UCHL1USP30 | |
| SCHEMBL5795681 | 0.78 | NOTUM (0.57) | ALDH1A1TSHRNOTUMAVPR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | GLP1R, GPR119, TRHR | UCHL1 4785/4885USP30 3752/4885ALDH1A1 3587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.