Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16739391 | 0.74 | TERT (0.49) | EGFRBACE1NPC1TERTAPP | |
| SCHEMBL16739386 | 0.74 | TERT (0.49) | EGFRBACE1NPC1TERTAPP | |
| SCHEMBL18226915 | 0.72 | TERT (0.46) | EGFRBACE1NPC1TERTAPP | |
| SCHEMBL28157132 | 0.72 | PDGFRB (0.49) | BACE1GRIN2BNPC1RAB9APDGFRB | |
| SCHEMBL6480883 | 0.69 | NPC1 (0.51) | EGFRNPC1TERTAPPRAB9A | |
| SCHEMBL29378182 | 0.69 | CYP1A2 (0.64) | APPPDGFRBPDGFRAKDM1ACYP1A2 | |
| SCHEMBL13356404 | 0.69 | MAPT (0.43) | EGFRNPC1APPRAB9ARXFP1 | |
| SCHEMBL14909225 | 0.68 | EGFR (0.59) | EGFRNPC1TERTAPPPDGFRB | |
| SCHEMBL18227073 | 0.68 | TERT (0.47) | EGFRBACE1NPC1TERTAPP | |
| SCHEMBL270025 | 0.66 | TERT (0.59) | EGFRNPC1TERTAPPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873670-B2 | Arylquinoline and analog compounds and use thereof to treat cancer | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2018-01-23 | — | — | US | claimed |
| US-20160280652-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-09-29 | — | — | US | claimed |
| WO-2015077550-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2015-05-28 | — | — | WO | claimed |
| US-9873670-B2 | Arylquinoline and analog compounds and use thereof to treat cancer | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160280652-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-09-29 | — | — | US | disclosed |
| US-20160280652-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-09-29 | — | — | US | disclosed |
| WO-2015077550-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280652-A1 | ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER | CASP4, BAD, BID | EGFR 2088/4885BACE1 1123/4885GRIN2B 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.