Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | UTRN | P46939 | 3/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491771 | 0.87 | NPC1 (0.56) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL6483701 | 0.74 | UTRN (0.48) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL30943188 | 0.70 | RAB9A (0.66) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL2139147 | 0.70 | RAB9A (0.66) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL24037863 | 0.70 | PTPN2 (0.50) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL16739382 | 0.69 | EGFR (0.48) | NPC1RAB9ACASP3RXFP1APP | |
| SCHEMBL11226194 | 0.69 | MAPT (0.55) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL12808067 | 0.69 | UTRN (0.52) | NPC1RAB9AAPPUTRNESR1 | |
| SCHEMBL11246114 | 0.69 | RAB9A (0.77) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL25028049 | 0.69 | NPC1 (0.72) | NPC1RAB9AMEN1CASP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | BF RESEARCH INSTITUTE (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | PRNP, PRPH, PCNP | NPC1 147/4885RAB9A 1787/4885MEN1 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.