Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.46 |
| ▸ | BCR | P11274 | 7/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579042 | 0.78 | ABL1 (0.46) | ABL1BCRDHFRPLK1KCNH2 | |
| SCHEMBL16747928 | 0.76 | IDH1 (0.45) | ABL1BCRDHFRKCNH2SCN5A | |
| SCHEMBL31220867 | 0.70 | DHODH (0.53) | ABL1BCRDHODHMAPTMEN1 | |
| SCHEMBL3395506 | 0.69 | ABL1 (0.67) | ABL1BCR | |
| SCHEMBL16739620 | 0.69 | TUBB4A (0.50) | DHFRMAPTMEN1NPC1RAB9A | |
| SCHEMBL16748003 | 0.68 | ALDH1A1 (0.43) | ABL1BCRDHFRDHODHMAPT | |
| SCHEMBL13821443 | 0.68 | ABL1 (0.50) | ABL1BCRMAPTKDM4EMAPK1 | |
| SCHEMBL16747852 | 0.67 | DHFR (0.43) | ABL1BCRDHFRMAPTMEN1 | |
| SCHEMBL16740150 | 0.66 | BMI1 (0.50) | ABL1BCRDHFRGALR2 | |
| SCHEMBL3996043 | 0.66 | EPHB4 (0.55) | ABL1BCRDHFRPLK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |