Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.34 |
| ▸ | BRD2 | P25440 | 9/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 9/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16244304 | 0.83 | BRD4 (0.42) | BRD4BRD2BRD3CREBBP | |
| SCHEMBL16244697 | 0.80 | CYP3A4 (0.36) | — | |
| SCHEMBL30611996 | 0.80 | CYP3A4 (0.36) | — | |
| SCHEMBL30943973 | 0.79 | CYP3A4 (0.35) | — | |
| SCHEMBL16268461 | 0.71 | PRMT5 (0.39) | BRD4BRD2BRD3CREBBP | |
| SCHEMBL16259901 | 0.67 | ALDH1A1 (0.41) | BRD4BRD2BRD3CREBBP | |
| SCHEMBL9388104 | 0.63 | KDM4E (0.44) | — | |
| SCHEMBL20429944 | 0.63 | NOS1 (0.38) | — | |
| SCHEMBL16261402 | 0.63 | KDM4E (0.38) | PDE2AYTHDC1 | |
| SCHEMBL25366120 | 0.61 | PIK3CA (0.36) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071571-A1 | PYRROLOPYRROLONE DERIVATIVES AND THEIR USE AS BET INHIBITORS | Novartis AG (CH) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015075665-A1 | PYRROLOPYRROLONE DERIVATIVES AND THEIR USE AS BET INHIBITORS | NOVARTIS AG (CH) | 2015-05-28 | — | — | WO | disclosed |