Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 10/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 10/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid Methyl Ester SCHEMBL31165941 | 0.78 | LTA4H (0.37) | LTA4HHPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL24409282 | 0.76 | CYP11B1 (0.37) | LTA4HHPGDSCCNCCDK8CCNK | |
| SCHEMBL12924082 | 0.76 | LTA4H (0.42) | LTA4HHPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL16742979 | 0.76 | LTA4H (0.35) | LTA4HADRB3HPGDS | |
| SCHEMBL16741221 | 0.73 | TPH1 (0.38) | CCNCCDK8 | |
| SCHEMBL12896119 | 0.73 | LTA4H (0.40) | LTA4HADRB3HPGDSCCNCCDK8 | |
| SCHEMBL2726596 | 0.71 | CA12 (0.42) | — | |
| Formic Acid Methyl Ester SCHEMBL31165950 | 0.70 | TUBB4A (0.34) | LTA4HHPGDSCCNCCDK8GABRA5 | |
| SCHEMBL12935880 | 0.70 | PPARG (0.35) | LTA4HADRB3HPGDSCCNKCDK12 | |
| SCHEMBL16741215 | 0.68 | LTA4H (0.35) | LTA4HADRB3HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071567-A1 | TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE | Actelion Pharmaceuticals Ltd (CH) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015075025-A1 | TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE | ACTELION PHARMACEUTICALS LTD (CH) | 2015-05-28 | — | — | WO | disclosed |