Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.34 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | GCG | P01275 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15686689 | 0.86 | PDGFRB (0.40) | PDGFRBPDGFRABACE1CYP1A2CYP2A6 | |
| SCHEMBL11322091 | 0.83 | OGA (0.40) | CYP1A2ESR2KDM4EKMT2A | |
| SCHEMBL13356681 | 0.82 | OGA (0.37) | AKR1C3AKR1C2KDM4EHRH4KMT2A | |
| SCHEMBL2667927 | 0.80 | ALDH1A1 (0.47) | PDGFRBPDGFRABACE1CYP1A2CYP2A6 | |
| SCHEMBL29904777 | 0.79 | PDGFRB (0.50) | PDGFRBPDGFRACYP1A2CYP2A6HRH4 | |
| SCHEMBL40697 | 0.79 | PDGFRB (0.50) | PDGFRBPDGFRACYP1A2CYP2A6HRH4 | |
| SCHEMBL9071490 | 0.78 | BACE1 (0.42) | BACE1ITGAVITGB6ITGB8KDM4E | |
| SCHEMBL13356662 | 0.78 | PDGFRB (0.42) | PDGFRBPDGFRACNR1CNR2AKR1C3 | |
| SCHEMBL20047698 | 0.76 | PDE10A (0.36) | — | |
| SCHEMBL20049318 | 0.76 | AKR1C3 (0.43) | CYP1A2CYP2A6AKR1C3AKR1C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030853-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2024-07-09 | — | — | US | disclosed |
| US-20210171461-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2021-06-10 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030853-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | PDGFRB 4632/4885PDGFRA 4842/4885BACE1 2314/4885 |
| US-20210171461-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | PDGFRB 4632/4885PDGFRA 4842/4885BACE1 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.