SCHEMBL16744472

SCHEMBL16744472

O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(C(O)(c2ccc3c(c2)COC3)c2ccc3c(c2)OCO3)CC1

nearest known ligand 0.84

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 12/20 0.84
▸ FAAH O00519 2/20 0.52
▸ ABHD6 Q9BV23 11/20 0.43
▸ PLA2G7 Q13093 3/20 0.41
▸ CYP2D6 P10635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29373207 0.92 MGLL (1.00) MGLLFAAHABHD6PLA2G7CYP2D6
SCHEMBL15100756 0.92 MGLL (0.68) MGLLABHD6PLA2G7CYP2D6
SCHEMBL15100615 0.92 MGLL (1.00) MGLLFAAHABHD6PLA2G7CYP2D6
SCHEMBL16744473 0.90 MGLL (0.68) MGLLFAAHABHD6PLA2G7
SCHEMBL16747546 0.89 MGLL (0.66) MGLLFAAHABHD6PLA2G7
SCHEMBL20408671 0.82 MGLL (0.81) MGLLFAAH
SCHEMBL16744470 0.81 MGLL (0.57) MGLLFAAHABHD6
SCHEMBL18210852 0.81 MGLL (0.53) MGLLABHD6PLA2G7
SCHEMBL16744471 0.81 MGLL (0.79) MGLLFAAHABHD6PLA2G7CYP2D6
SCHEMBL18634173 0.81 MGLL (0.78) MGLLFAAHABHD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 — — US disclosed
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 — — US disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 — — US disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABHD6, ABHD16A, PRMT6 MGLL 16/4885FAAH 10/4885ABHD6 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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