SCHEMBL1674749

SCHEMBL1674749

CC1=C(C)c2c(C)cc(C)cc2[CH]1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.33
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2A Q12879 1/20 0.30
GRIN2B Q13224 1/20 0.30
GRIN2C Q14957 1/20 0.30
GRIN3A Q8TCU5 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2051464 0.71
SCHEMBL28520267 0.70 TP53 (0.36) HSD17B10
SCHEMBL317299 0.69 RAPGEF4 (0.50) RAPGEF4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8161483 0.66 PDK2 (0.39) RAPGEF4
SCHEMBL27527197 0.65 PIM1 (0.44) RAPGEF4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL26200975 0.64 GRIN2D (0.39) RAPGEF4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11740491 0.62 RAPGEF4 (0.38) RAPGEF4
SCHEMBL2044930 0.62 TDP2 (0.43)
SCHEMBL28666918 0.62 RAPGEF4 (0.33) RAPGEF4
SCHEMBL24959765 0.62 RAPGEF4 (0.43) RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235917-B1 GROUP 3-6 OR LANTHANIDE METAL COMPLEXES POSSESSING TWO METAL CENTERS JOINED BY MEANS OF A DIVALENT BRIDGING GROUP JOINING TRIVALENT MOIETIES COMPRISING BORON OR A MEMBER OF GROUP 14 OF THE PERIODIC TABLE OF THE ELEMENTS THE DOW CHEMICAL COMPANY 2001-05-22 US claimed
EP-1377613-B1 METHOD OF MAKING INTERPOLYMERS AND PRODUCTS MADE THEREFROM DOW GLOBAL TECHNOLOGIES LLC (US) 2019-06-19 EP disclosed
EP-1412398-B1 HIGH MELT STRENGTH POLYMERS AND METHOD OF MAKING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2019-04-24 EP disclosed
CN-101143908-B Olefin polymer DOW GLOBAL TECHNOLOGIES INC. (US) 2011-12-14 CN disclosed
US-RE43004-E1 High melt strength polymers and method of making same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-12-06 US disclosed
US-7999039-B2 Catalytic polymerization of olefinic monomers in the presence of a high molecular weight catalyst and a low molecular weight catalyst in a polymerization reactor system; high melt strength DOW GLOBAL TECHNOLOGIES LLC (US) 2011-08-16 US disclosed
US-RE42276-E1 High melt strength polymers and method of making same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-04-05 US disclosed
CN-100519588-C Method of making polymer and polymer composition DOW GLOBAL TECHNOLOGIES INC (US) 2009-07-29 CN disclosed
US-7300983-B2 High melt strength polymers and method of making same DOW GLOBAL TECHNOLOGIES INC. (US) 2007-11-27 US disclosed
US-7271221-B2 Method of making interpolymers and products made therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2007-09-18 US disclosed
US-6235917-B1 GROUP 3-6 OR LANTHANIDE METAL COMPLEXES POSSESSING TWO METAL CENTERS JOINED BY MEANS OF A DIVALENT BRIDGING GROUP JOINING TRIVALENT MOIETIES COMPRISING BORON OR A MEMBER OF GROUP 14 OF THE PERIODIC TABLE OF THE ELEMENTS THE DOW CHEMICAL COMPANY 2001-05-22 US disclosed
EP-0910593-B1 ELASTOMERS AND PROCESS FOR THEIR MANUFACTURE DOW CHEMICAL CO (US) 2001-04-18 EP disclosed
CN-1258303-A Olefin polymers prepared with substituted indenyl containing metal complexes DOW CHEMICAL CO (US) 2000-06-28 CN disclosed
EP-0977787-A1 OLEFIN POLYMERS PREPARED WITH SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 2000-02-09 EP disclosed
US-6015868-A CATALYSIS OF HIGH TEMPERATURE, SOLUTION POLYMERIZATION WHICH YIELDS HIGH MOLECULAR WEIGHT OLEFIN POLYMERS, BY USING COORDINATION CATALYST MIXED WITH AN ACTIVATING COCATALYST, EFFICIENCY THE DOW CHEMICAL COMPANY (US) 2000-01-18 US disclosed
CN-1214699-A Highly soluble olefin polymerization catalyst activator DOW CHEMICAL CO (US) 1999-04-21 CN disclosed
CN-1200735-A Substituted indenyl contg. metal complexes and olefin polymerization process DOW CHEMICAL CO (US) 1998-12-02 CN disclosed
WO-1998049211-A1 OLEFIN POLYMERS PREPARED WITH SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1998-11-05 WO disclosed
EP-0874860-A1 SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND OLEFIN POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1998-11-04 EP disclosed
WO-1997015583-A1 SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND OLEFIN POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1997-05-01 WO disclosed