Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | C1R | P00736 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308703 | 0.83 | MEN1 (0.51) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL1308829 | 0.78 | NTRK1 (0.46) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL16312481 | 0.75 | TDP1 (0.45) | TERTTDP1 | |
| SCHEMBL29853560 | 0.75 | KDM4E (0.79) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL26767762 | 0.75 | KDM4E (0.79) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL14147750 | 0.74 | PTPRC (0.50) | MAPTKDM4ERAB9AALDH1A1MEN1 | |
| SCHEMBL28721954 | 0.73 | ALDH1A1 (0.55) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL29511516 | 0.73 | ALDH1A1 (0.55) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL7570047 | 0.72 | TERT (0.47) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL26768169 | 0.72 | MAPT (0.79) | MAPTKDM4ERAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682990-B2 | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160318946-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-03 | — | — | US | disclosed |
| US-9328073-B2 | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150148370-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318946-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | TOP1, TOP2A, TOP2B | MAPT 2900/4885KDM4E 1131/4885RAB9A 2294/4885 |
| US-20150148370-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | TOP1, TOP2A, TOP2B | MAPT 2900/4885KDM4E 1131/4885RAB9A 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.